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. 2022 Jun 9;10(6):1361. doi: 10.3390/biomedicines10061361

Table 2.

Summary of studies investigating the relationship between hormones and psychotherapy in individuals with anxiety disorders.

Hormone as Predictor of Therapeutic Change Hormone as Indicator of Therapeutic Change
Treatment Level Session Level Treatment Level Session Level
Hormone
Cortisol Phobias: Low levels during exposure predict worse outcomes [27,31,32,33,34,35] Social anxiety disorder: Low levels predict greater fear during exposure [33] Generalised anxiety disorder: Levels decrease over treatment [43,44,45,46,47,48,49,50]
Social anxiety disorder: No change [31,45]
Phobias: No change with exposure [27,31,44,45,48]
Oxytocin Phobias: High levels predict worse outcomes [67]
Social anxiety disorder: No effects on outcomes, but high levels predict better evaluation of appearance and speech performance [66]
- - -
Oestradiol Phobias: Low levels predict worse outcomes to exposure therapy but not cognitive therapy [80,81,82] Phobias: Low levels predict slower improvement during exposure [80] - -