Table 2.
Summary of studies investigating the relationship between hormones and psychotherapy in individuals with anxiety disorders.
Hormone as Predictor of Therapeutic Change | Hormone as Indicator of Therapeutic Change | |||
---|---|---|---|---|
Treatment Level | Session Level | Treatment Level | Session Level | |
Hormone | ||||
Cortisol | Phobias: Low levels during exposure predict worse outcomes [27,31,32,33,34,35] | Social anxiety disorder: Low levels predict greater fear during exposure [33] | Generalised anxiety disorder: Levels decrease over treatment [43,44,45,46,47,48,49,50] Social anxiety disorder: No change [31,45] |
Phobias: No change with exposure [27,31,44,45,48] |
Oxytocin | Phobias: High levels predict worse outcomes [67] Social anxiety disorder: No effects on outcomes, but high levels predict better evaluation of appearance and speech performance [66] |
- | - | - |
Oestradiol | Phobias: Low levels predict worse outcomes to exposure therapy but not cognitive therapy [80,81,82] | Phobias: Low levels predict slower improvement during exposure [80] | - | - |