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Effect of POL, CUR, QRC and the MIX on gene expression versus expression after HG treatment in sHUVEC.
| sHUVEC | IL-1B | IL-8 | miR-126 | |||
|---|---|---|---|---|---|---|
| Effect vs. HG (%) | Synergistic Effect * | Effect vs. HG (%) | Synergistic Effect * | Effect vs. HG (%) | Synergistic Effect | |
| POL | 26 | Y | 28 | Y | 50 | Y |
| CUR | 34 | 50 | 5 | |||
| QRC | 96 | 10 | 45 | |||
| MIX | 163 | 102 | 145 | |||
Y = Yes. * The effect of the three compounds (POL, CUR and QRC) taken together (MIX) is greater than the sum of their separate effect at the same doses.
