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. 2022 Jun 17;11(6):817. doi: 10.3390/antibiotics11060817

Table 5.

Topkat models (Mouse Female, Rat Female, Ames Mutagenicity, Skin Irritancy, Skin Sensitization and Ocular Irritancy) of clarithromycin, diclofenac and Ellagic Acid.

Compound Mouse Female Rat Female Ames Mutagenicity Skin Irritancy Skin Sensitization Ocular Irritancy
Clarithromycin NC NC NM Mild None Mild
Diclofenac NC NC NM None Strong Mild
Ellagic Acid NC NC NM None Strong Mild

Abbreviations: NC: non-carcinogen; NM: non-mutagen.