Table 6.

Toxicity risk prediction via TOPKAT (Rate oral LD50, Daphnia EC50, rat chronic LOAEL, fathead minnow LC50).

Compound	Rat Oral LD50 (g/kg Body Weight)	Rat Chronic LOAEL (g/kg Body Weight)	Fathead Minnow LC50 (g/L)	Daphnia EC50 (mg/L)
Clarithromycin	0.787	0.001	0.004	0.278
Diclofenac	0.564	0.034	0.002	9.665
Ellagic Acid	0.428	0.302	0.049	16.407

Abbreviations: Daphnia EC50 = the effect concentration of a substance that causes adverse effects on 50% of the test population (Daphnia magna); LOAEL—lowest observed adverse effect level; Fathead minnow—short-term toxicity to fish.