Table 3.
Top 30 upregulated genes in Fusarium-infected HCFs based on fold-change compared to uninfected controls.
| Gene | Description | Fold change | p value |
|---|---|---|---|
|
| |||
| HSPA6 | Heat Shock Protein Family A (Hsp70) Member 6 | 1,794 | .00005 |
| CXCL8 | chemokine involved in neutrophil recruitment and angiogenesis | 1,496 | .00005 |
| CSF3 | cytokine involved in granulocyte production and function | 1,308 | .00005 |
| CXCL2 | chemokine involved inflammation and angiogenesis | 895 | .00005 |
| CXCL3 | chemokine involved in neutrophil recruitment and angiogenesis | 651 | .00005 |
| C11orf96 | 537 | .00005 | |
| TNFAIP3 | TNF-α induced protein that inhibits NF-kappa-B activation and TNF-mediated apoptosis | 420 | .00005 |
| FOSB | Fos proto-oncogene, AP-1 transcription factor subunit implicated in cell proliferation and differentiation | 388 | .00005 |
| HSPA1A | Heat Shock Protein (Hsp70) family member | 263 | .00005 |
| IL11 | Gp130 cytokine family member that play a role in T-cell-dependent development of B-cells | 245 | .00005 |
| HSPA1B | Heat Shock Protein (Hsp70) family member | 213 | .00005 |
| TFPI2 | Kunitz-type serine proteinase inhibitor family | 212 | .00005 |
| G0S2 | G0/G1 switch 2 | 205 | .00005 |
| IL6 | cytokine involved in inflammation and B cell maturation | 199 | .00005 |
| MFSD2A | Sodium-dependent lysophosphatidylcholine transporter | 184 | .00005 |
| DNAJB1 | Heat Shock Family (Hsp40) member | 151 | .00005 |
| BIRC3 | IAP family member that inhibits serum- deprivation-induced apoptosis | 144 | .00005 |
| LIF | Leukemia Inhibitory Factor, IL-6 family cytokine | 123 | .00005 |
| NR4A3 | Nuclear receptor subfamily 4 A member 3 | 91 | .00005 |
| IL1A | cytokine involved in inflammation and hematopoiesis | 81 | .00005 |
| CXCL1 | chemokine involved in neutrophil recruitment | 70 | .00005 |
| NR4A2 | Nuclear receptor subfamily 4 A member 2 | 68 | .00005 |
| CLDN14 | Claudin 14 involved in cell-to-cell adhesion in epithelial and endothelial sheets | 63 | .00005 |
| ATF3 | mammalian Activation Transcription Factor/ CREB protein family of transcription factors | 61 | .00005 |
| NFKBIA | NF-kappa-B inhibitor family | 59 | .00005 |
| CD83 | Immunoglobulin superfamily of receptors involved in the regulation antigen presentation | 58 | .00005 |
| MMP1 | M10 family of matrix metalloproteinases that breaks down interstitial collagens | 57 | .00005 |
| NIPAL4 | NIPA like domain containing membrane receptor | 52 | .00005 |
| IL1B | cytokine involved in inflammation produced by activated macrophages | 51 | .00005 |
| TRIM36 | E3 ubiquitin-protein ligase | 50 | .00005 |