Figure 6.

A schematic overview of ANGPT2 signaling in health and in hypercoagulation with high levels of ANGPT2 inhibiting TM-mediated anticoagulation. Thrombin/TM normally catalyzes protein C (PC) to activated protein C (APC), which inhibits Factor VIIIa and Factor Va. Increased levels of ANGPT2 in mice reduces tail bleeding time and plasma APC, while increasing TAT. In critically ill COVID-19 patients, ANGPT2 is increased and correlates to reduced kidney function, hypercoagulation, and mortality.