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Applied methodology in machine learning development. The development of the prediction model was performed in two phases (a) Phase 1 and (b) Phase 2 as described. Outcome (Out)1, Out2, …, Out12 represent 12 global or regional knee cartilage volume losses at one year; In1, In2, …, In10 represent two OA risk factors and eight knee bone curvature regions. BMI, body mass index; RF, random forest; M5P, M5 prime; MLP, multilayer perceptron; ANFIS, adaptive neuro-fuzzy inference system.
