Figure 4.

Beeswarm and box plots revealing the temporal dynamic changes in the antinucleocapsid (N) protein IgG antibody levels of patients with lung cancer actively treated with ICIs and control patients, who did not receive anticancer drugs or immunosuppressive therapy, before and after vaccination with mRNA SARS-CoV-2 vaccine. Data for the 65 patients with lung cancer who were being actively treated with ICIs are illustrated with red dots and the data for 65 control patients are illustrated with blue dots; all patients received two doses of the BNT162b2 vaccine. Box plots display the median values with IQR (lower and upper hinges) ±1.5-fold the IQR from the first and third quartiles (lower and upper whiskers, respectively). The horizontal dotted line represents the manufacturer’s 1.4 S/C value (S/C: the chemiluminescent signal ratio between the samples and a calibrator). ICI, immune checkpoint inhibitor; IQR, interquartile range; mRNA; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2.