Table 1.
Cytotoxic activity (IC50 values) of ligands 4a-e and complexes 5a-e against human cancer cell lines. IC50 values were expressed as the mean ± SD determined from the results of MTT assay in three independent experiments. cis-DDP was used as a positive control.
| Compounds | IC50(μM) |
|||||
|---|---|---|---|---|---|---|
| HeLa | A549 | LS174 | A375 | K562 | MRC-5 | |
| 4a | 128.20 ± 15.37 | N/A | 170.46 ± 1.28 | 122.94 ± 7.17 | 162.77 ± 4.62 | 92.97 ± 0.59 |
| 4b | 81.84 ± 9.57 | 122.72 ± 6.05 | 153.13 ± 9.08 | 102.41 ± 6.26 | 95.88 ± 1.85 | 28.17 ± 0.32 |
| 4c | 121.80 ± 12.83 | N/A | 185.11 ± 5.50 | 157.58 ± 7.84 | 193.00 ± 3.75 | 88.92 ± 6.31 |
| 4d | 138.99 ± 7.64 | N/A | >200 | 199.58 ± 0.59 | 194.61 ± 7.62 | 169.13 ± 8.98 |
| 4e | 156.55 ± 6.52 | N/A | 195.55 ± 2.87 | 175.58 ± 2.90 | 197.00 ± 0.54 | 114.33 ± 2.36 |
| 5a | 34.70 ± 1.23 | 61.99 ± 0.36 | 67.43 ± 1.24 | 14.14 ± 1.11 | 11.44 ± 1.19 | 32.46 ± 0.47 |
| 5b | 16.39 ± 0.43 | 24.87 ± 1.14 | 32.78 ± 3.38 | 14.00 ± 0.10 | 11.45 ± 0.15 | 14.81 ± 2.16 |
| 5c | 17.89 ± 0.7 | 33.85 ± 2.74 | 34.00 ± 1.39 | 13.94 ± 0.25 | 8.63 ± 0.24 | 14.28 ± 0.66 |
| 5d | 69.66 ± 4.33 | N/A | 81.79 ± 4.28 | 199.53 ± 0.67 | 198.09 ± 1.58 | 66.49 ± 4.73 |
| 5e | 78.28 ± 3.26 | N/A | 97.77 ± 1.43 | 116.66 ± 5.72 | 130.48 ± 3.13 | 57.17 ± 1.18 |
| cisplatin | 2.36 ± 0.28 | 17.93 ± 0.44 | 20.8 ± 0.44 | 2.56 ± 0.42 | 5.56 ± 0.23 | 4.26 ± 0.46 |