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Proliferation curve of MC3T3-E1 cells treated with or without KR-12-3 and KR-12 for 1–4 days (a). Data are shown as mean ± SD; n = 3. MC3T3-E1 cells stained with AO/EB (green: live; red: dead) after 1–4 days of incubation in the absence (control) and presence of KR-12-3 at 25 µg mL−1 (b). (b) shows the results of 0–4 d of co-culturing of PBS or KR-12-3 and Mc3t3-e1 cells, respectively. The experiments were all repeated at least 3 times.
