Table 3.
Psychometric data, serotonin content (serum/platelet), and serotonergic activity of healthy participants and patients with depression.
| Variables | Healthy Controls | Patients with Depression | Statistics |
|---|---|---|---|
| Total number of subjects | 89 | 89 | |
| Psychometry | |||
| HAMD-21 a (mean ± SD) | 1.48 ± 2.00 | 18.56 ± 5.21 | t(176) = 28.9, p < 0.001 *** |
| BDI-II d (mean ± SD) | 3.83 ± 5.12 | 33.25 ± 10.46 | t(176) = 23.8, p < 0.001 *** |
| STAI-X1 b (mean ± SD) | 33.33 ± 7.98 | 55.36 ± 12.34 | t(176) = 14.2, p < 0.001 *** |
| STAI-X2 c (mean ± SD) | 32.64 ± 7.20 | 60.56 ± 9.20 | t(176) = 22.6, p < 0.001 *** |
| Serotonin content | |||
| Platelet serotonin content (109/Thr) (mean ± SD) (n = 71) |
2008.8 ± 1026.4 | 1113.9 ± 964.1 | t(142) = −5.4, p < 0.001 *** |
| Serum serotonin content (ng/mL) (mean ± SD) (n = 87) |
773.8 ± 646.0 | 230.9 ± 326.0 | t(172) = −6.1, p < 0.001 *** |
| Serotonergic activity | |||
| Cortical LDAEP (mean ± SD) (n = 66) |
0.252 ± 0.119 | 0.256 ± 0.186 | t(130) = 0.15, p = 0.855 |
| Source LDAEP (left) (mean ± SD) (n = 66) |
0.269 ± 0.512 | 0.207 ± 0.204 | t(130) = −0.92, p = 0.362 |
| Source LDAEP (right) (mean ± SD) (n = 66) |
0.253 ± 0.498 | 0.191 ± 0.245 | t(130) = −0.90, p = 0.371 |
*** p < 0.001; a Hamilton = HAMD-21; b State Anxiety Inventory = STAI-X1; c Trait Anxiety Inventory = STAI-X2; d Beck Depression Inventory = BDI-II.