Table 1.
Statistical summary of the top 25 metabolic and cellular pathways found in the integrated joint pathway analysis of significantly differentially expressed genes and important metabolites found in heat-stressed granulosa cells.
| Pathways | Total /Hits |
Raw p-Value |
Holm Adjust p-Value |
|---|---|---|---|
| ABC transporters | 198/18 | 5.1 × 10−11 | 1.7 × 10−8 |
| Central carbon metabolism in cancer | 103/11 | 6.5 × 10−8 | 2.1 × 10−5 |
| Aminoacyl-tRNA biosynthesis | 118/10 | 2.3 × 10−6 | 7.4 × 10−4 |
| Protein digestion and absorption | 168/11 | 8.7 × 10−6 | 2.8 × 10−3 |
| Glycine, serine, and threonine metabolism | 93/8 | 2.2 × 10−5 | 7.0 × 10−3 |
| Mineral absorption | 84/6 | 6.5 × 10−4 | 2.1 × 10−1 |
| Vitamin B6 metabolism | 36/4 | 1.0 × 10−3 | 3.3 × 10−1 |
| Vitamin digestion and absorption | 65/5 | 1.3 × 10−3 | 4.3 × 10−1 |
| Relaxin signaling pathway | 136/7 | 1.6 × 10−3 | 5.3 × 10−1 |
| Dilated cardiomyopathy (DCM) | 102/6 | 1.8 × 10−3 | 5.7 × 10−1 |
| Arginine biosynthesis | 42/4 | 1.9 × 10−3 | 5.9 × 10−1 |
| Taste transduction | 112/6 | 2.9 × 10−3 | 9.1 × 10−1 |
| Arrhythmogenic right ventricular cardiomyopathy (ARVC) | 78/5 | 3.0 × 10−3 | 9.4 × 10−1 |
| Tyrosine metabolism | 117/6 | 3.6 × 10−3 | 1.00000 |
| Phenylalanine metabolism | 83/5 | 3.9 × 10−3 | 1.00000 |
| Cocaine addiction | 56/4 | 5.3 × 10−3 | 1.00000 |
| Tryptophan metabolism | 129/6 | 5.8 × 10−3 | 1.00000 |
| Glyoxylate and dicarboxylate metabolism | 92/5 | 6.1 × 10−3 | 1.00000 |
| TGF-beta signaling pathway | 93/5 | 6.3 × 10−3 | 1.00000 |
| Hypertrophic cardiomyopathy (HCM) | 95/5 | 6.9 × 10−3 | 1.00000 |
| Axon guidance | 180/7 | 7.7 × 10−3 | 1.00000 |
| GABAergic synapse | 99/5 | 8.2 × 10−3 | 1.00000 |
| Alanine, aspartate and glutamate metabolism | 65/4 | 9.0 × 10−3 | 1.00000 |
| Apelin signaling pathway | 149/6 | 1.1 × 10−2 | 1.00000 |
| Histidine metabolism | 70/4 | 1.2 × 10−2 | 1.00000 |