Table 6.
Major diseases and their directly-associated metabolites and genes from the network analysis are listed. “Degree” denotes the number of direct connections among nodes and “Betweenness” shows the centrality of the given interaction. The list of interaction network nodes is given against each corresponding disease along with its regulation status in the heat-stressed granulosa cells.
| Id | Disease | Degree | b/w | Metabolites | Genes |
|---|---|---|---|---|---|
| 181500 | SCHIZOPHRENIA | 10 | 1086 | ↓Progesterone, ↑L-Lysine, ↓Serotonin, ↑Citric acid, ↑L-Glutamine, ↓Threonine, ↓Aminoadipic acid |
↓VEGFA |
| 104300 | ALZHEIMER DISEASE | 8 | 542 | ↑L-Lysine, ↑L-Leucine, ↑L-Glutamine, ↑Choline, ↓L-Proline, ↓Threonine |
- |
| 616299 | LIPOYLTRANSFERASE 1 DEFICIENCY | 5 | 286 | ↑L-Lysine, ↑L-Leucine, ↑L-Glutamine, ↓Succinic acid, ↓L-Proline, ↓Threonine |
- |
| 271900 | CANAVAN DISEASE | 4 | 453 | ↓Uridine, ↓Xanthine, ↑Citric acid, ↓Succinic acid | - |
| 617290 | EPILEPSY, VITAMIN B6-DEPENDENT | 3 | 203 | ↓Pyridoxal, ↑Pyridoxine, ↑L-Leucine |
- |
| 276700 | TYROSINEMIA, TYPE I | 3 | 56 | ↓Threonine, ↑L-Tyrosine, ↑L-Lysine |
- |
b/w: betweenness; ↑: up-regulated in heat stress; ↓: down-regulated in heat stress.