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. 2022 Jun 4;12(6):789. doi: 10.3390/biom12060789

Table 1.

Antifungal classification according to structure and mechanism of action [7].

Inside the Structure Mechanism of Action
Polyene Antifungal classification: a look inside the structure
Nystatin, natamycin, and amphotericin B
Antifungals that act on the cytoplasmatic membrane
Azoles Imidazole: miconazole, clotrimazole, and ketoconazole
Triazoles: fluconazole and itraconazole
(ketoconazole)
Antifungals that act on the cytoplasmatic membrane
Allylamines Terbinafine and naftifine Antifungals that act on the cytoplasmatic membrane
Lipopeptides Papulacandins and glycosylated triterpenes echinocandins: caspofungin, anidulafungin, and micafungin Antifungals that act on the cell wall
Pyrimidines Flucytosine Antifungals that act on the cell nucleus
Other Ciclopirox potassium iodide, tolnaftate, and griseofulvin Antifungals that act on the cell nucleus