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Mechanism of Ub-dependent versus UbID degradation by the proteasome. (A) Ubiquitin-dependent degradation occurs via ATP-dependent engagement, deubiquitination unfolding, and translocation. (B) Ubiquitin-independent degradation requires transient unfolding of the substrate, which is then captured by the 20S in an ATP-independent manner. It is unknown if the substrate still enters via the 19S pore.
