Table 1.
Mean (SD) TFI, TFI-22 global and subscale scores according to the Clinical Global Impression (CGI) categories and Minimal Clinically Important Difference (MCID) for ‘improved’ and ‘worsened’ categories for each subscale at follow-up administrations.
| T1 | T2 | T3 | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| CGI | n | Mean (SD) | MCID | n | Mean (SD) | MCID | n | Mean (SD) | MCID | |
| TFI | Much improved | 8 | −37.2 (22.9) | −33.1 | 19 | −29.4 (16.5) | −22.3 | 14 | −29.1 (19.9) | −20.0 |
| Moderately improved |
22 | −16.6 (16.5) | −12.6 | 15 | −21.7 (17.7) | −14.6 | 21 | −22.8 (18.5) | −13.7 | |
| Slightly improved | 39 | −12.8 (10.2) | −8.8 | 33 | −12.7 (11.8) | −5.6 | 24 | −12.0 (16.7) | −2.9 | |
| No change | 101 | −4.1 (12.0) | 67 | −7.1 (13.5) | 48 | −9.1 (12.7) | ||||
| Slightly worse | 23 | 2.5 (12.1) | 6.5 | 30 | 1.4 (14.9) | 8.5 | 33 | −0.7 (16.1) | 8.4 | |
| Moderately worse | 3 | −2.5 (11.4) | 1.5 | 9 | 6.0 (13.4) | 13.2 | 14 | 7.2 (20.5) | 16.3 | |
| Much worse | 2 | 12.2 (22.3) | 19.3 | 11 | 8.1 (10.3) | 17.2 | ||||
| TFI-22 | Much improved | 8 | −37.7 (23.3) | −32.7 | 19 | −31.4 (17.4) | −23.8 | 14 | −31.9 (19.2) | −21.9 |
| Moderately improved |
22 | −18.4 (18.1) | −13.5 | 15 | −21.4 (17.0) | −13.8 | 21 | −24.7 (18.3) | −14.6 | |
| Slightly improved | 39 | −13.5 (10.9) | −8.5 | 33 | −14.7 (12.4) | −7.1 | 24 | −14.7 (17.0) | −4.7 | |
| No change | 101 | −4.9 (12.0) | 67 | −7.6 (14.5) | 48 | −10.0 (13.6) | ||||
| Slightly worse | 23 | 2.4 (14.0) | 7.4 | 30 | 0.4 (15.4) | 8.0 | 33 | −2.1 (17.0) | 7.9 | |
| Moderately worse | 3 | −3.6 (11.8) | 1.3 | 9 | 4.2 (13.5) | 11.9 | 14 | 5.8 (21.6) | 15.8 | |
| Much worse | 2 | 11.8 (22.5) | 19.4 | 11 | 6.3 (10.7) | 16.3 | ||||
| INT | Much improved | 8 | −54.6 (24.2) | −47.6 | 19 | −36.5 (24.2) | −24.6 | 14 | −35.7 (19.8) | −17.5 |
| Moderately improved |
22 | −16.4 (18.0) | −9.4 | 15 | −25.3 (25.0) | −13.4 | 21 | −30.3 (14.8) | −12.1 | |
| Slightly improved | 39 | −15.1 (16.5) | −8.1 | 33 | 19.7 (18.1) | −7.8 | 24 | −21.1 (23.3) | −2.9 | |
| No change | 101 | −7.0 (22.4) | 67 | −11.9 (18.1) | 48 | −18.2 (22.6) | ||||
| Slightly worse | 23 | −4.2 (23.8) | 2.8 | 30 | 3.9 (23.5) | 15.8 | 33 | −8.4 (22.5) | 9.8 | |
| Moderately worse | 3 | −11.1 (15.4) | −4.1 | 9 | 2.6 (16.1) | 14.5 | 14 | 3.1 (19.5) | 21.3 | |
| Much worse | 2 | 5.0 (7.1) | 16.9 | 11 | 7.9 (26.0) | 26.1 | ||||
| SOC | Much improved | 8 | −50.8 (27.2) | −46.7 | 19 | −40.5 (21.8) | −30.8 | 14 | −34.5 (30.0) | −24.4 |
| Moderately improved |
22 | −19.4 (28.6) | −15.2 | 15 | −21.6 (26.9) | −11.8 | 21 | −24.6 (23.6) | −14.5 | |
| Slightly improved | 39 | −15.3 (17.7) | −11.1 | 33 | −19.4 (16.0) | −9.6 | 24 | −15.1 (22.4) | −5.0 | |
| No change | 101 | −4.2 (18.3) | 67 | −9.8 (23.7) | 48 | −10.1 (20.2) | ||||
| Slightly worse | 23 | −0.6 (14.1) | 3.6 | 30 | −0.9 (26.0) | 8.9 | 33 | −4.6 (18.7) | 5.5 | |
| Moderately worse | 3 | 36.7 (49.8) | 40.8 | 9 | 3.7 (12.6) | 13.5 | 14 | 4.3 (33.0) | 14.4 | |
| Much worse | 2 | 11.7 (16.5) | 21.4 | 11 | 5.5 (10.1) | 15.6 | ||||
| COG | Much improved | 8 | −32.5 (25.0) | −27.7 | 19 | −24.9 (22.6) | −20.1 | 14 | −23.8 (28.4) | −17.1 |
| Moderately improved |
22 | −13.9 (21.9) | −9.1 | 15 | −13.9 (20.4) | −8.7 | 21 | −20.6 (26.7) | −13.9 | |
| Slightly improved | 39 | −7.1 (18.8) | −2.3 | 33 | −11.0 (17.8) | −6.2 | 24 | −16.9 (25.8) | −10.2 | |
| No change | 101 | −4.8 (21.6) | 67 | −4.8 (19.5) | 48 | −6.7 (15.4) | ||||
| Slightly worse | 23 | 3.5 (20.7) | 8.3 | 30 | 0.8 (18.9) | 5.6 | 33 | 1.4 (22.0) | 8.1 | |
| Moderately worse | 3 | −2.2 (19.0) | 2.6 | 9 | 5.9 (17.9) | 10.7 | 14 | 7.6 (32.6) | 14.4 | |
| Much worse | 2 | 20.0 (47.1) | 24.8 | 11 | 4.8 (21.0) | 11.6 | ||||
| SLP | Much improved | 8 | −29.6 (39.4) | −24.8 | 19 | −36.8 (29.8) | −30.2 | 14 | −23.8 (28.4) | −11.4 |
| Moderately improved |
22 | −24.2 (28.0) | −19.4 | 15 | −18.9 (19.9) | −12.2 | 21 | −20.6 (26.7) | −8.3 | |
| Slightly improved | 39 | −10.9 (26.7) | −6.0 | 33 | −15.5 (31.9) | −8.8 | 24 | −16.9 (25.8) | −4.6 | |
| No change | 101 | −4.8 (22.1) | 67 | −6.7 (25.7) | 48 | −12.4 (26.1) | ||||
| Slightly worse | 23 | 0.9 (19.0) | 5.7 | 30 | 0.2 (18.8) | 6.9 | 33 | 1.4 (22.0) | 13.8 | |
| Moderately worse | 3 | −5.6 (5.1) | −0.7 | 9 | 10.4 (17.0) | 17.0 | 14 | 7.6 (32.6) | 20.0 | |
| Much worse | 2 | 15.0 (21.2) | 21.7 | 11 | 4.8 (21.0) | 17.2 | ||||
| AUD | Much improved | 8 | −33.3 (29.2) | −36.3 | 19 | -14.9 (22.1) | −11.5 | 14 | −16.7 (25.1) | −14.2 |
| Moderately improved |
22 | −3.5 (18.4) | −6.4 | 15 | −23.6 (26.7) | −20.2 | 21 | −8.9 (28.0) | −6.4 | |
| Slightly improved | 39 | −9.1 (18.2) | −12.1 | 33 | 1.5 (21.0) | 4.9 | 24 | 7.5 (27.3) | 10.0 | |
| No change | 101 | 2.9 (23.7) | 67 | −3.4 (18.8) | 48 | −2.5 (17.5) | ||||
| Slightly worse | 23 | 2.9 (26.8) | 0.0 | 30 | 9.9 (24.2) | 13.3 | 33 | 9.4 (25.5) | 11.9 | |
| Moderately worse | 3 | −3.3 (10.0) | −6.3 | 9 | 19.3 (22.3) | 22.6 | 14 | 20.2 (32.7) | 22.7 | |
| Much worse | 2 | 15.0 (21.2) | 18.4 | 11 | 20.6 (22.2) | 23.1 | ||||
| REL | Much improved | 8 | −52.9 (32.3) | −45.8 | 19 | −38.9 (33.5) | −29.0 | 14 | −42.4 (24.1) | −29.3 |
| Moderately improved |
22 | −23.6 (24.5) | −16.5 | 15 | −21.1 (24.2) | −11.2 | 21 | −25.2 (31.4) | −12.2 | |
| Slightly improved | 39 | −16.2 (19.4) | −9.1 | 33 | −17.5 (25.6) | −7.6 | 24 | −17.5 (25.8) | -4.4 | |
| No change | 101 | −7.1 (23.5) | 67 | −9.9 (21.7) | 48 | −13.1 (24.8) | ||||
| Slightly worse | 23 | 3.5 (23.6) | 10.6 | 30 | −2.3 (27.8) | 7.6 | 33 | −3.7 (22.6) | 9.3 | |
| Moderately worse | 3 | −5.6 (13.5) | 1.5 | 9 | −1.1 (8.7) | 8.8 | 14 | 4.8 (34.8) | 17.8 | |
| Much worse | 2 | 10.0 (14.1) | 19.9 | 11 | 3.9 (10.9) | 17.0 | ||||
| QOL | Much improved | 8 | −27.2 (27.6) | −23.7 | 19 | −21.7 (19.6) | −15.6 | 14 | −21.3 (20.9) | −16.9 |
| Moderately improved |
22 | −14.8 (22.8) | −11.3 | 15 | −24.6 (24.4) | −18.5 | 21 | −22.1 (27.1) | −17.7 | |
| Slightly improved | 39 | −13.6 (14.3) | −10.1 | 33 | −5.4 (17.8) | 0.7 | 24 | −9.3 (20.7) | −4.9 | |
| No change | 101 | −3.5 (19.3) | 67 | −6.1 (20.6) | 48 | −4.4 (17.6) | ||||
| Slightly worse | 23 | 8.0 (21.7) | 11.5 | 30 | 3.6 (23.5) | 9.7 | 33 | 3.7 (20.9) | 8.1 | |
| Moderately worse | 3 | −10.0 (8.7) | −6.5 | 9 | 7.2 (28.2) | 13.3 | 14 | 9.1 (24.2) | 13.5 | |
| Much worse | 2 | 13.8 (19.4) | 19.8 | 11 | 9.1 (19.0) | 13.4 | ||||
| EMO | Much improved | 8 | −30.4 (20.8) | −25.4 | 19 | −26.0 (24.1) | −20.7 | 14 | −23.8 (27.2) | −14.1 |
| Moderately improved |
22 | −17.7 (23.8) | −12.7 | 15 | −28.0 (26.6) | −22.7 | 21 | −22.4 (24.2) | −12.7 | |
| Slightly improved | 39 | −14.0 (20.8) | −9.0 | 33 | −18.2 (24.6) | −12.9 | 24 | −15.6 (21.6) | −5.8 | |
| No change | 101 | −5.1 (17.6) | 67 | −5.3 (18.8) | 48 | −9.7 (22.5) | ||||
| Slightly worse | 23 | 0.9 (20.1) | 5.9 | 30 | −0.3 (23.9) | 4.9 | 33 | −6.6 (23.5) | 3.2 | |
| Moderately worse | 3 | 7.8 (22.7) | 12.8 | 9 | 0.0 (27.1) | 5.3 | 14 | 4.0 (26.9) | 13.8 | |
| Much worse | 2 | 6.7 (33.0) | 11.9 | 11 | 7.6 (12.2) | 17.3 | ||||
INT = Intrusiveness, SOC = Sense of control, COG = Cognition, SLP = Sleep, AUD = Auditory, REL = Relaxation, QOL = Quality of life, and EMO = Emotional distress. T1 = 3-month follow-up, T2 = 6-month follow-up, T3 = 9-month follow-up; SD = standard deviation.