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. 2022 Jun 16;12(6):421. doi: 10.3390/bios12060421

Table 3.

Comparison of specific combinations of SNAs in PCR amplification process.

Detection Method Strategy Target Detection Limit Detection Range Ref.
Colorimetric Using two kinds of primer-functionalized AuNPs. DNA over 20 nt 0.1 fM — [83]
Colorimetric Silica coating and closed-tube method. DNA 105 copies — [86]
Colorimetric Utilized the oxyethyleneglycol-bridged primers. Genomic DNA 4.3 fM 16 fM to 1.6 nM [94]
Colorimetric SNAs act as TaqMan-like signal probe. DNA and protein 0.4 pM for DNA; 0.57 nM for protein 1.0 pM to 100 nM for DNA; 1.0 nM to 20 μM for protein [97]
DLS SNAs act as TaqMan-like signal probe. DNA and protein 1.1 fM for DNA; 1.0 pM for protein 3.0 fM to 1.0 nM for DNA; 2.0 pM to 200 nM for protein [97]