Figure 5. Enhanced insulin secretion from mitochondrial PEP in β-Zfp148^KO islets.

Fractional secretion from islets of chow-fed male β-Zfp148^KO (red circles and traces) and control (open circles, black traces) mice during a low-glucose ramp of GDH activator BCH in perifusion. Dotted vertical lines indicate transitions between the different solutions. All solutions contained 2 mM glucose (Gluc) and 2 mM l-glutamine (Gln). Concentration of BCH is indicated above each respective segment of the perifusion traces. n = 4/genotype. **P < 0.01, Šidák post test after 2-way ANOVA of AUC of the segment, β-Zfp148^KO vs. control islets. Trace points display mean ± SEM. There was no difference in insulin content per islet between groups (data not shown).