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. 2022 May 23;7(10):e149107. doi: 10.1172/jci.insight.149107

Figure 6. 2-OHE1 and 4-OHE1 potentiate AITC-induced [Ca2+]i responses in DRG neurons.

Figure 6

(A and B) Preapplication of 100 pM 2-OHE1 (B) but not vehicle (A) for 10 minutes potentiated 5 μM AITC-induced [Ca2+]i responses in DRG neurons isolated from WT mice. (C) Bar charts show the potentiating effect of 2-OHE1 on 5 μM AITC-induced [Ca2+]i responses in a dose-dependent manner. (D and E) Effects of vehicle (D) and 100 pM 4-OHE1 (E) on 5 μM AITC-induced [Ca2+]i responses in DRG neurons isolated from WT mice. (F) Bar charts illustrate the potentiating effect of 4-OHE1 on 5 μM AITC-induced [Ca2+]i responses in a dose-dependent manner. *P < 0.05, **P < 0.01, ****P < 0.0001, 1-way ANOVA, n = 3–6 coverslips from at least 3 mice (>200 neurons each).