Figure 9. Genetic ablation of TRPA1 but not TRPV1 significantly inhibits pain-related behaviors in a mouse model of uterine pain induced by estrogen in ovariectomized female mice implanted with estrogen pellets.

(A) Representative images illustrate heatmaps of voluntary movements of WT, Trpv1^–/–, and Trpa1^–/– mice subjected to 3 days of estrogen treatment followed by oxytocin application. (B–E) Statistical data show the number of writhing responses (B), total moving distance (C), total time spent moving (D), and total time spent stationary (E) in WT, Trpa1^–/–, and Trpv1^–/– mice subjected to 3 days of estrogen treatment followed by oxytocin application. **P < 0.01, ***P < 0.001, n = 6, 1-way ANOVA.