Figure 1.

Immunostaining of the SNc with antibodies against full-length $\mathsf{\alpha }$-synuclein (KM51) or aggregated $\mathsf{\alpha }$-synuclein (5G4). Representative images of immunostaining against full length synuclein (KM51) and aggregated synuclein (5G4) in sections from the SNc of the same individual. Arrowheads show punctate inclusions, arrows show cytoplasmic and extracellular Lewy bodies and dense bodies. There is a higher level of immunopositive grains and threads, as well as inclusions in glial cells (recognized based on morphology; red arrowhead) in tissue stained with the 5G4 antibody. Neuromelanin is marked with an asterisk. Scalebar: 50 $\mathsf{\mu }$m.