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. 2022 May 23;7(10):e153079. doi: 10.1172/jci.insight.153079

Figure 3. Photoinactivation of catalase sensitizes a wide range of pathogenic bacteria to H2O2.

Figure 3

(A–H) CFU/mL of stationary-phase S. enterica ATCC 29630 (A), stationary-phase E. coli BW25113 (B), stationary-phase A. baumannii 1 (C), stationary-phase P. aeruginosa strains (D–F), Klebsiella pneumonia 1 (G), and Enterococcus faecalis 1 (H) under various treatment schemes. 410 nm exposure: 6.6 J/cm2, H2O2: 22 mM, 30-minute culture time (for A–H). (I) Toxicity test of CHO cells by MTT assay under different treatment schemes. (J–L) CFU/mL of log-phase MRSA USA300 (J), log-phase P. aeruginosa PAO1 (K), and log-phase A. baumannii 1 (L) under different treatment schemes. 410 nm exposure: 75 J/cm2, H2O2: 0.1%. Serial dilution or MTT assay was conducted after 1-minute incubation time (for I–L). Data: Mean + SD from 3 replicates for all panels. Pound sign indicates the CFU results are below the detection limit. Significant difference was determined by Student’s 2-tailed unpaired t test and 1-way ANOVA. Significant difference from all the other groups unless noted. ***P < 0.001; **P < 0.01.