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. 2022 May 23;7(10):e159090. doi: 10.1172/jci.insight.159090

Figure 4. Pathology of the liver, spleen, and lung of SUDV-challenged rhesus macaques that succumbed at 9–12 dpi.

Figure 4

Representative photomicrographs of IHC at 20× original magnification for SUDV VP40 antigen (brown) in the liver (A, E, I, and M), spleen (B, F, J, and N), and lung (C, G, K, O). IHC positivity for rare Kupffer cells/mononuclear cells (black arrows) in the liver of D5-RDV-1 (A), small clusters in D6-RDV-3 (E) and D6-MBP-3 (I), and moderate clusters in D6-COMB-5 (M). IHC positivity for scattered mononuclear cells within the red and white pulp of the spleen for D5-RDV-1 (B), rarely the white pulp (black arrow) and red pulp (white arrow) D6-RDV-3 (F), and moderately in D6-COMB-5 (N). No appreciable immunolabeling was present in the spleen of D6-MBP-3 (J). Mononuclear cells had IHC positivity within clustered/nodular lesions of the lung of D5-RDV-1 (C, arrows), D6-RDV-3 (G, arrow), D6-MBP-3 (K, arrow), and D6-COMB-5 (O). Multifocal raised white nodules consistent with pneumonia on histology were present in D6-COMB-5 at gross examination (D). Representative positive ISH (red) at 20× original magnification of pulmonary nodules for D6-RDV-3 (H), D6-MBP-3 (L), and D6-COMB-5 (P).