Skip to main content
. 2022 May 23;7(10):e157874. doi: 10.1172/jci.insight.157874

Figure 8. Schematic diagram of pericyte-associated FGF-2/FGFR1/AHR/CXCL14 axis recruits and polarizes TAMs in facilitating NPC metastasis.

Figure 8

(A) NPC cancer cells often produce FGF-2, and FGF-2 primarily targets pericytes and fibroblasts. In FGF-2+ tumors, vascular-associated pericytes and CAFs express various inflammatory regulating cytokine/chemokines. Among them, CXCL14 is produced exclusively by pericytes through FGF-2/FGFR1/AHR signaling. CXCL14 signaling recruits and polarizes TAMs into an M2-like phenotype. M2-like TAMs facilitate tumor cell intravasation and pulmonary metastasis.