Figure 4.
(A) BAX/Bcl2 ratio in control keratinocytes treated with CBD (4 μM) or AEA (4 μM) or irradiated with UVB (60 mJ/cm2) as well as cells irradiated with UVB and treated with CBD or AEA (in the same concentrations). (B) BAX/Bcl2 ratio in keratinocytes after treatment with 20 μM celecoxib alone and with CBD(4 μM) or AEA(4 μM) or irradiated with UVB (60 mJ/cm2) as well as cells irradiated with UVB and treated with CBD or AEA (in the same concentrations). (a)—statistically significant differences between keratinocytes treated with CBD, AEA, UVB, UVB + CBD, AEA + UVB and non-treated cells as well as keratinocytes treated with CBD + celecoxib, AEA + celecoxib, UVB + celecoxib, UVB + CBD + celecoxib and AEA + UVB+ celecoxib and cells treated only with celecoxib; p < 0.05; (b)—statistically significant differences between keratinocytes treated with UVB + CBD, UVB + AEA, UVB + CBD + celecoxib, AEA + UVB + celecoxib and irradiated with UVB p < 0.05; (c)—statistically significant differences between keratinocytes treated with celecoxib and corresponding keratinocytes not treated with celecoxib.