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. 2022 Jun 11;11(12):1894. doi: 10.3390/cells11121894

Figure 7.

Figure 7

RIP3−/− mice exhibit decreased levels of cGAS, STING, and p-p65 after renal I/R. (A) Immunoblots and graph showing increases in STING levels after renal I/R compared to sham group in WT mice. However, in RIP3−/− mice, the levels of STING were reduced when compared to littermate WT mice after renal I/R. Note that there was no difference in the levels of STING between WT and RIP3−/− sham mice. Values are expressed as means ± SEM; * p < 0.05 versus WT sham group; # p < 0.05 versus WT-I/R (n = 3/group). (B) Immunoblots and graph showing an increase in p-p65 levels after renal I/R compared to sham in WT mice. However, in RIP3−/− mice, the levels of p-p65 were reduced when compared to littermate WT mice after renal I/R. Note that there was no difference in the levels of p-p65 between WT and RIP3−/− sham mice. Values are expressed as means ± SEM; * p < 0.05 versus WT sham group; # p < 0.05 versus WT-I/R (n = 4/group). (C) Immunoblots and graph showing increases in cGAS levels after renal I/R compared to sham in WT mice. However, in RIP3−/− mice, the levels of cGAS were reduced when compared to littermate WT mice after renal I/R. Note that there was no difference in the levels of cGAS between WT and RIP3−/− sham mice. Values are expressed as means ± SEM; * p < 0.05 versus WT sham group; # p < 0.05 versus WT-I/R (n = 4/group).