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. 2022 May 23;7(10):e150070. doi: 10.1172/jci.insight.150070

Figure 2. Correlation of TCR clonal breadth with nAb titers.

Figure 2

(A–F) Class II HLA–restricted TCRs (A–C) or class I HLA–restricted TCRs (D–F) were assigned to antigens from the SARS-CoV-2 spike protein (A and D), nucleocapsid phosphoprotein (NP; B and E), and other viral proteins (C and F), and clonal breadth of assigned sequences was correlated with nAb titers. Correlations for spike class II–associated T cells (A); NP class II–associated T cells (B); other class II T cells (C); spike class I–associated T cells (D); NP class I–associated T cells (E); and other class I T cells (F) with nAb titer. Data are expressed as median ± IQR (n = 357). Partial correlations were assessed by Spearman’s rank-order correlation.