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. 2022 May 23;7(10):e152762. doi: 10.1172/jci.insight.152762

Figure 10. Effect of Kp-10 on human ASM proliferative signaling pathways.

Figure 10

Western blot analysis showed PDGF-induced activation of p38 (A) Akt (B), and ERK1/2 (C) in human ASM cells. Pretreatment with Kp-10 significantly reduced the PDGF-induced phosphorylation of p38, Akt, and ERK1/2. Data are reported as a minimum to maximum of 6 individual samples from people without asthma and analyzed using 1-way ANOVA followed by Tukey’s post hoc test. *P < 0.05 vs. vehicle; #P < 0.05, ##P < 0.01 vs. PDGF-exposed groups.