Figure 14. Chronic placental inflammation with preeclampsia leads to unique clustering of intermediate monocyte gene expression.

Intermediate monocytes (n = 23) with known placental pathology and associated clinical features also divided into 3 hierarchical clusters. Group A was composed of preterm deliveries complicated by preeclampsia and placental vascular lesions. Group B was composed of preterm deliveries complicated by preeclampsia and placental vascular lesions, and this group’s patients also had high degree chronic inflammatory lesions. Group C was composed of preterm deliveries with chorioamnionitis and placental inflammation. Genes related to leukocyte activity, function, migration, and degranulation were upregulated in Group C. Genes related to lipid metabolism and organic cyclic compound processing were upregulated in Groups A and B. There were 1852 differentially expressed genes based on an FDR < 0.05 and 2-fold change using DeSeq2.