Figure 8. WGCNA of placental domains and their associated clinical phenotypes reveal unique cluster of classical monocyte gene expression.

WGCNA of classical monocyte samples (n = 34) with available placental pathology and pregnancies complicated by clinical findings associated with that placental pathology reveals modules that are unique to each group. Genes related to platelet interactions were present in Module 1 (M1) and highly expressed in the inflammation and term groups. M2 contained genes related to inflammatory cytokines based on GO biological processes that were relatively upregulated in the preterm group. Genes related to antigen presentation were found in M3 and were relatively upregulated in the term group. Genes related to processes like artery development, such as VEGFA, were expressed in term neonates but were lower in preterm neonates exposed to placental pathology.