Figure 9. Gene expression of classical monocytes from preterm dyads cluster based on associated clinical findings and placental pathology.

Classical monocytes (n = 23) with known placental pathology and associated clinical features were divided into 2 hierarchical clusters. Group A was composed of preterm deliveries with chorioamnionitis and placental inflammation. Group B was composed of preterm deliveries complicated by preeclampsia MVM lesions. Genes related to granulocyte function were upregulated in Group A, while genes related to cell proliferation were upregulated in Group B. Based on an FDR < 0.05 and 2-fold change, there were 598 differentially expressed genes using DeSeq2.