TABLE 4.

MiRNAs regulate SLC15, SLC 19, SLC22, and SLCO family transporters.

Transporters	Substrates	miRNAs	Models	Findings	References
SLC15A1/PEPT1	Di-/tri-peptides 5-aminolevulinic acid	miR-92b-3p	Intestinal epithelial cells Colorectal adenocarcinoma cell line Caco2-BBE	Transfection with miR-92b precursor downregulates SLC15A1 mRNA by about 40%	Dalmasso et al. (2011)
		miR-193-3p	Colorectal adenocarcinoma cell lines Caco2, HT29 cells, and kidney 293T cells Clinical ulcerative colitis and normal samples female C57BL/6 mice, dnTGFβRII mice, and C57BL/6 mice	Transfection of miR-193a-3p mimic downregulated SLC15A1 protein by about 80%, while miR-193a-3p inhibitor increased SlC15A1 levels by about 5-fold	Dai et al. (2015)
SLC19A1/RFC1 with rs1051296 G > T polymorphism	Folate Methotrexate	miR-595-3p	Lymphoblastic leukemia cell line CEM-C1	Transfection with miR-595 mimic reduced SLC19A1 protein by about 50%	Wang et al. (2018)
SLC22A7/OAT2	Prostaglandin E2 Aminohippuric acid	miR-29a-3p	Hepatocellular carcinoma cell line HepG2, hepatic cell line HepaRG, and kidney 293T cells	Transfection with miR-29a-3p mimic reduced SLC22A7 mRNA by 63% and protein by 66%	Yu et al. (2015)
SLC22A18/ORCTL2	Organic cations	miR-137-3p	Non-small-cell lung cancer cell lines H522 and H23 100 non-small-cell lung cancer and paracancerous samples	Transfection with miR-137 mimics decreased SLC22A18 protein level by about 60%	Zhang et al. (2015)
SLCO4A1	Organic anion	miR-150-3p	Colon cancer cell line HCT116 and colon cell line NCM460 Xenograft mouse model	Transfection with miR-150-3p reduced SLCO4A1 mRNA by about 50% and protein by about 40%. LncRNA SLCO4A1-AS1 sponges miR-150-3p	Wu et al. (2021)
SLCO1B3	Organic anions Androgens	miR-579-3p	Prostate cancer cell lines 22Rv1, LNCaP, and VCAP cell lines	miR-579-3p downregulated SLCO1B3 and abiraterone reduced miR-579-3p expression	Barbier et al. (2021)