Figure 5. miR-10b is the most transcriptionally activated microRNA in FLC.

(A) Gene expression (RNA-Seq signal, n = 19, top row) or transcriptional activity (ChRO-Seq signal, n = 13, bottom row) for the 17 significantly differentially expressed microRNAs (after removing isomiRs) is shown as the log₂ FC in FLC versus NML. (B) miR–483-5p and (C) miR–10b-5p genome browser tracks showing normalized ChRO-Seq signal. The upper and lower panel show the activity in FLC and NML. Activity on the plus and minus strand are shown in red and gray, respectively. The mature microRNA sequence is shown as a gray rectangle, the promoter region of the miRNA is shown as a black rectangle, and the direction of transcription is identified by an arrow. Predicted FOXQ1 bindings sites in the miR-10b promoter are identified by blue dashes.