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. 2022 May 23;7(10):e158889. doi: 10.1172/jci.insight.158889

Figure 3. OMCPmutIL-2 facilitates JAK phosphorylation but does not signal through canonical JAK/STAT pathway like IL-2 family of cytokines.

Figure 3

(A) Canonical signaling pathways described for common γ chain cytokines. (B) JAK1 and JAK3 total and phosphorylated levels by Western blot analysis after in vitro activation with anti-CD3/28 stimulation and in the presence of IL-2, IL-15, OMCPmutIL-2, or control (saline). (C) Phospho-STAT5 levels in CD8+ T cells activated with IL-2, IL-15, OMCPmutIL-2, or saline control in the presence of anti-CD3/28. *P < 0.05; **P < 0.01; ***P < 0.001; t test.