Table 1.
Demographic characteristics and imaging data of controls, early AD and late AD groups.
| Control (n = 37) |
Early AD (n = 16) |
Late AD (n = 15) |
p Value | |
|---|---|---|---|---|
| CU/CI (n/n) | 37/0 | 4/12 | 0/15 | <0.001 a,b |
| Female, n (%) | 21 (56.8%) | 11 (68.8%) | 11 (73.3%) | 0.46 |
| Age (years) | 64.9 (6.4) | 66.9 (8.9) | 70.5 (5.5) | 0.04 b |
| Education (years) | 9.9 (3.7) | 10.7 (1.1) | 9.4 (1.1) | 0.78 |
| HKLLT Z-score | 0.25 (−1.08, 0.71) | −1.80 (−2.19, −0.91) | −2.03 (−2.24, −2.03) | <0.001 a,b |
| MoCA | 25.58 (3.55) | 21.81 (5.88) | 15.07 (4.61) | <0.001 b,c |
| Global PIB retention | 1.26 (0.05) | 1.58 (0.17) | 1.68 (0.20) | <0.001 a,b |
| Global T807 SUVR | 1.03 (0.07) | 1.23 (0.22) | 1.27 (0.19) | <0.001 a,b |
| Hippocampal fraction (%) | 0.58 (0.09) | 0.50 (0.07) | 0.40 (0.05) | <0.001 b,c |
Values are expressed as mean with standard deviation for normal distribution data, otherwise expressed as median with interquartile range. AD: Alzheimer’s disease; CU: cognitively unimpaired; CI: cognitively impaired; HKLLT: Hong Kong List Learning Test; MoCA: Montreal Cognitive Assessment score; PIB: 11C-Pittsburgh compound B tracer; T807: 18F-flortaucipir; SUVR: standardized uptake value ratio. a Statistically significant difference between controls versus early AD (p < 0.05); b Statistically significant difference between controls versus late AD (p < 0.05); c Statistically significant difference between early AD versus late AD (p < 0.05).