Figure 1.

An unsupervised hierarchical cluster analysis based on the total concentrations of lipid metabolites in pretransplant serum samples derived from 93 allogeneic stem cell transplant recipients. In this analysis, we included the total serum concentrations of lysophophatidylcholine (LPC), lysophosphatodylethanolamine (LPE), phosphatidylinositol (PI), cholesteryl esters (CE), sphingolipid/lactosylceramide (LCER), diacylglycerols (DAG) and monoacylglycerols (MAG); the lipid levels were significantly altered when comparing recipients with and without signs of inflammation and/or patients with and without later acute GVHD grade 2–4. Green indicates low levels, while purple indicates high levels of metabolites for individual patients. The column to the far right indicates the three patient subsets identified by clustering, showing varied levels of lipids.