Table 3.
The differences in serum lipid profiles between allotransplant recipients with and without preconditioning signs of inflammation or later development of acute GVHD; a summary of the overall results. The table presents the p values for those seven out of 14 investigated lipid classes/subclasses that showed statistically significant differences when comparing their total levels for patients with and without inflammation and acute GVHD. A more detailed presentation showing the number of significantly altered metabolites for each of the two comparisons (i.e., with and without inflammation/GVHD, respectively), together with the corresponding r values is given in Table S1.
| Main Group of Lipids | Lipid Subset | Inflammation | Acute GVHD |
|---|---|---|---|
| p Value | p Value | ||
| Lysophosphatidylcholine | LPC Ester | 0.0001 | |
| Lysophosphatidylethanolamine | LPE Ester | 0.0491 | |
| Phosphatidylinositol | PI Ester | 0.0315 | |
| Cholesteryl Ester | CE Ester | 0.0197 | |
| Sphingolipids | Lactosylceramide | 0.0227 | |
| Diacylglycerols | DAG ester | 0.0335 | |
| Monoacylglycerols | MAG Ester | 0.0158 |
Total serum levels were determined for the 14 lipid classes phosphatidylcholines, lysophosphatidylcholines (LPC), phosphatidylethanolamines, lysophosphatidylethanolamines (LPE), phosphatidylinositols (PI), ceramides, dihydroceramides, hexosylceramides, lactosylceramides, sphingomyelins, cholesteryl esters (CE), diacyglycerols (DAG), triacylglycerols and monoacylglycerols.