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. 2022 Jun 8;11(12):1868. doi: 10.3390/cells11121868

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Strategies to improve the amount of CFTR channels at the plasma membrane (PM). CFTR correctors (red) interact directly with CFTR to improve its folding and subsequent trafficking. Targeting CFTR interactors through proteostasis modulation (orange) allows mutant CFTR to escape early degradation and traffic to the PM. Stabilizers (blue) prolong the duration of CFTR’s residence at the PM by slowing down its turn-over and peripheral degradation. ERQC: Endoplasmic Reticulum Quality Control; PQC: Peripheral Quality Control.