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Different types of CFTR correctors. Left: The F508del-CFTR protein is misfolded and does not achieve the native conformation of wild-type (WT)-CFTR. Schematic overview of folding defects associated with the F508del mutation. Right: Type I, II, and III correctors tackle different folding defects, which alone or in combination (partially) rescue F508del to a more WT-like state.
