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. 2022 Jun 12;11(12):1905. doi: 10.3390/cells11121905

Table 2.

Clinical and histopathological scores from DSS mice models.

Evaluation GRflox (n = 10) GRiKO (n = 8)
Rectal bleeding (% of mice at day 7) 40 59
Rectal bleeding severity (% of mice at day 7) 5% severe, 20% mild 18% severe, 36% mild
Colon length (cm) 6.7 ± 0.2 5.9 ± 0.1
Body weight loss (% of initial weight) *** 91 ± 1 86 ± 1
Disease activity index (DAI) *** 1.8 ± 0.2 3.15 ± 0.15
Pathological Scores:
Inflammation (p = 0.06) 2.3 ± 0.4 3.4 ± 0.3
Erosion * 2.1 ± 0.6 3.8 ± 0.1
Atrophy 2.9 ± 0.5 3.7 ± 0.2
Fibrosis 2.5 ± 0.4 2.9 ± 0.1
Edema * 1.3 ± 0.5 3 ± 0.7

* p < 0.05; *** p < 0.001.