Table 2.
Evaluation | GRflox (n = 10) | GRiKO (n = 8) |
---|---|---|
Rectal bleeding (% of mice at day 7) | 40 | 59 |
Rectal bleeding severity (% of mice at day 7) | 5% severe, 20% mild | 18% severe, 36% mild |
Colon length (cm) | 6.7 ± 0.2 | 5.9 ± 0.1 |
Body weight loss (% of initial weight) *** | 91 ± 1 | 86 ± 1 |
Disease activity index (DAI) *** | 1.8 ± 0.2 | 3.15 ± 0.15 |
Pathological Scores: | ||
Inflammation (p = 0.06) | 2.3 ± 0.4 | 3.4 ± 0.3 |
Erosion * | 2.1 ± 0.6 | 3.8 ± 0.1 |
Atrophy | 2.9 ± 0.5 | 3.7 ± 0.2 |
Fibrosis | 2.5 ± 0.4 | 2.9 ± 0.1 |
Edema * | 1.3 ± 0.5 | 3 ± 0.7 |
* p < 0.05; *** p < 0.001.