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. 2022 Jun 11;14(12):2886. doi: 10.3390/cancers14122886

Figure 3.

Figure 3

CD1a x CD3ε BTCE in vitro functional activity. (A) Activation markers (CD69, CD25) on CD8-CD4 T lymphocytes of vehicle or co-cultured with T-ALL cells at a 10:1 E:T ratio in the presence of vehicle or increasing concentration of CD1a x CD3ε BTCE. (B) Cytotoxic enzyme production (perforin, granzyme, and granulysin), cytokine release (IFN-y, TNF-a and IL-2) on T lymphocytes co-cultured with T-ALL cells in the presence of vehicle, or increasing concentration of CD1a x CD3ε BTCE. (C) Representative FACS data of CD25 and CD69 on cell membrane of PBMCs co-cultured with T-ALL cells at a 10:1 E:T ratio in the presence of vehicle or increasing concentration of CD1a x CD3ε BTCE; * p < 0.05, ** p < 0.01, *** p < 0.001.