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. 2022 Jun 11;14(12):2886. doi: 10.3390/cancers14122886

Figure 4.

Figure 4

CD1a x CD3ε BTCE in vitro activity is mediated by T cell. (A) Schematic representation of experimental design. (B) Relative percentage (%) of T-cell redirected cytotoxicity of PBMCs, CD4, and CD8 depleted lymphocytes co-cultured with T-ALL cells in the presence of increasing concentrations of the BTCE. (C) Relative percentage (%) of T-cell redirected cytotoxicity of PBMCs, CD56 depleted, CD56 enriched, and PBMCS Fc blocked co-cultured with T-ALL cells in the presence of increasing concentration (0.01,0.1 and 1 µg/mL) of the BTCE. (D) CD1a x CD3ε BTCE direct cytotoxicity in the absence of effector cells on T-ALL cell lines. (E) Proliferation of T-cells co-cultured with CCRF-CEM, HPB-ALL, and TALL-1 cells, respectively, in the presence of the BTCE. * p < 0.05, *** p < 0.001.