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S6K and 4E-BP in mRNA translation. When mTORC1 is activated, 4E-BP is phosphorylated and inactive, and LARP1 is phosphorylated and binds to the 3′ UTRs of RP mRNAs, promoting their translation. When mTORC1 is inactivated, 4E-BP binds to eIF4E and inhibits eIF4F complex formation. S6K1 binds to eIF3 complex to block translation initiation. LARP1 directly binds to 5′ caps, 5′ TOP sequences, and 3′ UTRs of RP mRNAs and inhibits their translation.
