Figure 4.

Summary of the relationships between somatic mutations in primary and PDX tumors based on DNA-seq results. (a) Heatmap analysis of the DNA profiling in tissues of the PDX and primary tumors using the AmpliSeq Cancer Hotspot Panel v 2. In all cases, gene mutations in primary (P) and PDX (F0 and F2) tumors were found to be highly correlated. (b) Variant allele frequencies (VAFs) of somatic mutations identified in P and F0 tumors. The lower-left graph shows a scatter plot and linear regression of the VAF levels in the P and F0 tumors. The diagonal graph shows the kernel density estimation (KDE). In most cases, P and F0 tumors show a high correlation whereas PDX99 tumor show a low correlation.