Figure 2.

ITSC derivatives effectively protect against neurotoxicity caused by Aβ42 in SK-N-SH cells: (a) Mixtures of either M or FMp (1 and 2 μΜ) with Aβ42 (1 μΜ) were incubated for 24 h at 37 °C and then added to cells for 24 h. Negative control cells were treated with ITSCs alone in the same conditions. (b) Cells were treated with either M or FMp (1 μM) for 1, 3, 5 and 24 h prior to the addition of Aβ42 (1 μΜ) for 24 h. (c) Cells were treated for 24 h with 1 μΜ of Aβ42 followed by a 24 h treatment with 1 μΜ of M or FMp. Significance relative to control (a) and to Aβ42 (b,c). Results were expressed as the mean ± s.d. for at least three independent experiments and analyzed using one-way ANOVA (**** p < 0.0001).