Table 3.

Structure and mechanism of hRR subunit inhibitors.

Structure	Name	RR Subunit Targeted	Mechanism of RR Inhibition
	P6	RR1	Prevents binding of the RR2 subunit
	P7	RR1	Prevents binding of the RR2 subunit
	p-Alkoxyphenols	RR2	Quenches the tyrosyl radical
	ADP-S-HBES-S-dGTP	RR1	Targets the S-site
	A167	RR1	Compeites with ATP to bind the A-site
	5-NITP	RR1	S-site inhibitor that prevents RR1 hexamerization
	DHS	RR2	Induces degradation of RR2 proteosome degredation pathway
	OxolsolndoLys	RR1	Induces formation of inactive a6 hexamers
	NSAH	RR1	Reversible C-site inhibitor
	TP6	RR1	Reversible C-site inhibitor
	NSC73735	RR1 and RR2	Prevents alpha subunit hexamerization and quenches the tyrosyl radical of RR2
	Ti(HBED)	RR2	Depletes intracellular labile iron pools by transmetalation
	Ti(Deferasirox)2	RR2	Depletes intracellular labile iron pools by transmetalation