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Summary illustrations for Chi–Au nanocomposites in in vitro and in vivo assessments. The summary shows that Chi combined with 50 ppm of Au nanoparticles can significantly induce neural differentiation. Furthermore, the animal model also indicated Chi–Au 50 ppm was a highly safe nanocomposite, indicating its potential for use in tissue engineering. The up and down arrows indicated the increased or decreased expression of protein and mRNA.
