Table 2.
Clinicopathologic characteristics of patients with pT3N0 colorectal cancer according to the addition of adjuvant chemotherapy in the overall cohort.
| Adjuvant Chemotherapy (n = 772) | No Adjuvant Chemotherapy (n = 853) |
p Value | |
|---|---|---|---|
| Age, mean ± SD, years | 59 ± 10 | 67 ± 11 | <0.001 |
| Sex | |||
| Male | 468 (60.7) | 496 (58.2) | |
| Female | 304 (39.3) | 357 (41.8) | |
| Location | <0.001 | ||
| Colon | 492 (63.7) | 664 (77.8) | |
| Rectum | 280 (36.3) | 189 (22.2) | |
| Poorly differentiated | 29 (3.8) | 20 (2.3) | 0.116 |
| <12 LN harvested | 6 (0.8) | 11 (1.3) | 0.311 |
| Lymphovascular invasion | 280 (36.3) | 104 (12.2) | <0.001 |
| Perineural invasion | 176 (22.8) | 95 (11.1) | <0.001 |
| Preoperative obstruction | 236 (30.6) | 199 (23.3) | 0.001 |
| Involved resection margin | 12 (1.6) | 10 (1.2) | 0.506 |
| MSI-H | 73 (9.5) | 95 (11.1) | 0.128 |
| No. of high-risk features | <0.001 | ||
| No | 245 (31.7) | 528 (61.9) | |
| 1 | 351 (45.5) | 238 (27.9) | |
| ≥2 | 176 (22.8) | 87 (10.2) |
LN, lymph nodes; MSI-H, microsatellite high frequency; No., number; SD, standard deviation.