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. 2022 Jun 15;14(12):2955. doi: 10.3390/cancers14122955

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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The role of LIF in adipocytes. LIF can activate the phosphorylation of STAT1 and STAT3, increase ATGL to lead to lipolysis, and is associated with decreased LPL activity. Finally, it results in triglyceride loss in adipocytes. LIF also can induce WAT browning, a thermogenic process. Meanwhile, LIF may inhibit preadipocytes’ differentiation to mature adipocytes, as evidenced by the inhibition of PPAR-γ, C/EBP-α, and FABP4 expression (by Figdraw “www.figdraw.com”, accessed on 5 May 2022).