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. 2022 Jun 7;11(12):1865. doi: 10.3390/cells11121865

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Myh9 deletion alters expression of genes responsible for HSC maintenance. (A) Pie chart showing the numbers of differentially expressed genes in Myh9-deficient LSK cells 4 days after first poly I:C injection. (B) Heat map showing interested genes involved in regulation of HSC self-renewal, survival, and maintenance. Genes with * are significantly up- or down- regulated. (C–K) Gene set enrichment analysis showed significant alterations of genes related to hematopoietic stem cells, myeloid cells, survival, and mTOR signal pathways in Myh9^fl/fl:Mx1-cre LSK cells compared with control LSK cells 4 days after first poly I:C injection. (L) Expression level of genes from selected gene sets were confirmed by real time PCR (n = 3). Data are shown as mean ± SD.